Our lab investigates local and spatial re-organization of chromatinized replication forks in response to replication stress. We use a combination of super-resolution 

 imaging, genomics and proteomics based approaches to understand the complex mechanisms of chromatin regulation in maintaining replication fork stability in normal as well as cancer cells.

LATEST LAB NEWS:

see the latest cover featuring our lab here: https://digitaalpubliceren.com/erasmusmc/21305/48-49/

• We received a Daniel den Hoed/Erasmus MC Foundation BRIDGING grant to further validate our ChromStretch assay for predicting chemotherapy response in ovarian cancer patients prior to treatment. For more information and an overview of our lab, see the Erasmus MC/Amazing Erasmus feature here: Amazing Erasmus MC story

• We received an ERC-Proof of Concept grant PRECISE to validate our assay in efficiently predicting the response of chemotherapy in retrospective ovarian cancer patients. - Januaray 2026 For more information, see here:   Amazing Erasmus MC story; Oncode story

• We received a € 1 million KWF grant together with Francesca Mattiroli (Hubrecht Institute) and Aniek Janssen (UMC Utrecht) to study how heterochromatin is rebuilt during DNA replication and how its alteration drives cancer growth and therapy response. - December 2025

• We secured € 150.000 Oncode Technology Development Funding to develop a clinical-grade ChromStretch Assay for predicting therapy response in tumor cells. - December 2024

• Our lab received an EU-HORIZON Marie Skłodowska-Curie Fellowship for a new postdoc! - February 2025

Stay tuned on our latest research in upcoming meetings