3-D Chromatin Remodeling &
Replication
'single molecule to whole genome'
Copyright 2023 @Taneja lab
Our lab investigates local and spatial re-organization of chromatinized replication forks in response to replication stress. We use a combination of super-resolution
imaging, genomics and proteomics based approaches to understand the complex mechanisms of chromatin regulation in maintaining replication fork stability in normal as well as cancer cells.
LATEST LAB NEWS:
- We received an ERC-Proof of Concept grant PRECISE to validate our assay in efficiently predicting the response of chemotherapy prior to treatment in ovarian cancer patients. - Januaray 2026 For more information, see here: Amazing Erasmus MC story; Oncode story
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We received a € 1 million KWF grant together with Francesca Mattiroli (Hubrecht Institute) and Aniek Janssen (UMC Utrecht) to study how heterochromatin is rebuilt during DNA replication and how its alteration drives cancer growth and therapy response. - December 2025
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We secured € 150.000 Oncode Technology Development Funding to develop a clinical-grade ChromStretch Assay for predicting therapy response in tumor cells. - December 2024
- Our lab received an EU-HORIZON Marie Skłodowska-Curie Fellowship for a new postdoc! - February 2025
Stay tuned on our latest research in upcoming meetings
We are invited at following events, please register by clicking on the meeting link below:
2024:
.3rd Subhash Mukhopadhyay Symposium 2024
.EMBO Workshop: Evolution and diversity of the DNA damage response 2024
.Seminar series organized by the IMCR, University of Zurich, Switzerland 2024
.Seminar series organized by the CS&D Utrecht Medical Center Utrecht, Netherlands 2024
.EMBO Workshop: Chromatin dynamics and nuclear organization in genome maintenance 2024
.EMBO | EMBL Symposium: DNA replication: from basic biology to disease 2024
.6th International Meeting on Chromosome Stability, JNCASR Bangalore, December 13-17 2024
2025:
. 4R-RTG I R-loop Club with Dr. Nitika Taneja - Joint event with SFB1361 2025
. Challenges in DNA Repair I Workshop @ Lorentz Center Leiden 2025
. Keystone Symposia: DNA Replication Gaps, Cancer and Disease, Daejeon, South Korea, 2025
. Fusion Conference: 2ndBalancing Genome Fidelity & Plasticity Conference, Lisbon, Portugal, 2025
. Birmingham Center for Genome Biology (BCGB Conference), Birmingham, UK, 2025
. Seminar series at Genome Integrity and Cancers Department at Gustave Roussy, Paris, France, 2025
. Seminar at IFOM, The AIRC Institute of Molecular Oncology, Milan, Italy, 2025
2026:
. The 22nd Aaxia Telangiectasia Workshop (ATW), 2026
. GiiN (Genome Integrity Italian Network) webinar, 2026
. 12th Quinquennial Conference on Responses to DNA damage, Egmond aan Zee, The Netherlands, 2026
. Seminar Series from University of Nebraska Medical Center, Department of Genetics, Cell Biology and Anatomy
.7th International Meeting on Chromosome Stability, IISER Trivandrum, Kerala, December 14-17 2026
2027:
. Keystone Symposia on DNA Replication: Pathway Crosstalk Shaping Physiology and Disease. London, UK, 2027
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Funding
 2020-2022 Pawe%c5%82 Kuna Permission is hereby granted%2c free of charge%2c to any person obtaining a copy of this software and associated documentation files (the 'Software')%2c to deal in the Software without restriction%2c including without limitation the rights to use%2c copy%2c modify%2c merge%2c publish%2c distribute%2c sublicense%2c and/or sell copies of the Software%2c and to permit persons to whom the Software is furnished to do so%2c subject to the following conditions: The above copyright notice and this permission notice shall be included in all copies or substantial portions of the Software. THE SOFTWARE IS PROVIDED 'AS IS'%2c WITHOUT WARRANTY OF ANY KIND%2c EXPRESS OR IMPLIED%2c INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY%2c FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM%2c DAMAGES OR OTHER LIABILITY%2c WHETHER IN AN ACTION OF CONTRACT%2c TORT OR OTHERWISE%2c ARISING FROM%2c OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE. %3c/schema:copyrightNotice%3e%3c/rdf:Description%3e%3c/rdf:RDF%3e%3c/metadata%3e%3cpath stroke='none' d='M0 0h24v24H0z' fill='none'/%3e%3ccircle cx='9' cy='7' r='4'/%3e%3cpath d='M3 21v-2a4 4 0 0 1 4 -4h4a4 4 0 0 1 4 4v2'/%3e%3cpath d='M16 3.13a4 4 0 0 1 0 7.75'/%3e%3cpath d='M21 21v-2a4 4 0 0 0 -3 -3.85'/%3e%3c/svg%3e)
